The shift comes despite the Rams still holding a 2-3 record and remaining near the top of the odds board.
There is a new favorite to win Super Bowl LXI. Sportsbooks now list the 49ers ahead of the Rams, who had held the top spot for much of the season.
The move follows another marquee loss for the Rams on Monday night, though they still sit near the top of the board despite a 2-3 record. The Bills and Ravens round out the group just behind the new co-favorites.
Elsewhere in the odds, the Jaguars are closing in on the Ravens and Chiefs, a sign that the league's betting landscape is shifting well before the stretch run. None of this locks anything in, but it does show how quickly perception can change based on a single prime-time result.
For now, the 49ers and Rams share the top of the market, with Buffalo and Baltimore keeping pace just behind them. Expect the numbers to keep moving as more divisional and conference games play out.