Center Drew Kendall, safety Marcus Epps and receiver Hollywood Brown are also ruled out, while Jalen Hurts is dealing with a calf issue but will play.
The Philadelphia Eagles will take the field in London without their top running back and leading receiver. Saquon Barkley and DeVonta Smith have both been ruled out for Sunday's game against the Jacksonville Jaguars because of hamstring injuries.
They are not alone on the inactive list. New starting center Drew Kendall, safety Marcus Epps and receiver Hollywood Brown were also ruled out, leaving the Eagles thin at multiple spots. Quarterback Jalen Hurts was added to the injury report with a calf issue but is expected to play.
The absences come in the aftermath of a difficult stretch for Philadelphia, which lost to the Los Angeles Rams in Week 4, traded Cam Jurgens and saw Lane Johnson retire. With Barkley and Smith sidelined, Hurts and the rest of the offense will have to find a way to move the ball against Jacksonville without two of their most reliable playmakers.