San Francisco gets a chance to tighten its grip on the NFC West when Seattle comes to town.
The 49ers host the Seahawks this week with a shot to establish full control of the NFC West, the marquee matchup on an otherwise unspectacular Week 5 schedule.
The NFL continues its trip abroad for a second straight weekend, with the Eagles facing the Jaguars in London. Other notable games on the slate include Buccaneers against Cowboys and Bears against Packers.
Monday Night Football closes out the week with a quarterback matchup between Josh Allen and the Bills against Matthew Stafford and the Rams.
Pickers around the league are divided on much of the slate. One outlet noted this was a week where the majority of picks required extra deliberation given the number of unknowns across the league. Last week's picks saw one outlet go 10-6, pushing its season-long record to 36-27 heading into this week's 16-game preview.