The Ravens quarterback hurt his throwing hand on Baltimore's opening snap against the Bills and was quickly ruled out, as Buffalo rolled Baltimore 36-10.
Lamar Jackson's return from a three-game absence with an ankle injury lasted exactly one play. On the Ravens' opening offensive snap in Orchard Park, Jackson's throwing hand hit the arm of Bills pass rusher Greg Rousseau as he attempted a pass. He immediately left the field and was taken to the locker room by the team's medical staff.
The Ravens initially listed Jackson as questionable to return before officially ruling him out with a right thumb injury. He was later seen wearing a hard brace on the hand. Backup Tyler Huntley took over under center, but Baltimore couldn't recover, falling to Buffalo 36-10.
The injury adds a new wrinkle to an already complicated situation for Jackson, who had been expected to use this season to push toward a first Super Bowl appearance and a new contract that would make him the NFL's highest-paid player again. Instead, the two-time MVP is now dealing with a second injury in as many return attempts, leaving his status and the Ravens' plans at quarterback uncertain heading into their next game.